This genetic disorder follows an autosomal recessive pattern, meaning that both parents must donate a copy of the gene (in which case each parent is a carrier of the mutated gene) to their child, who has a 1 in 4 chance of being born with Bloom syndrome. New York: McGraw-Hill, Inc., 1993.īloom syndrome (also known as telangiectatic erythema) is a rare inherited disorder that can result in the appearance of small red capillaries (telangiectases) on affected areas of skin, delayed growth at birth, small stature, immunodeficiency, infertility, mental retardation and an increased likelihood of developing cancer. “Abnormal Responses to Ultraviolet Radiation: Idiopathic.” Dermatology in This drug, however, is a teratogen, meaning it has the potential to harm a developing fetus, and should therefore be avoided during pregnancy. Thalidomide has been found to be effective in treating the disorder when prescribed at a low-dosage. Because normal sun protectors are not very effective in reducing the likelihood of an outbreak, the best way to prevent rashes is to avoid exposure to sunlight as much as possible. Those that experience later onsets of the disorder are twice as likely to be female.ĭamage done to exposed skin does not seem to be minimized when using sunscreens, including those that have high SPFs. Those suffering from the disorder will usually develop their first rashes by ten years old. People with darker skin most often develop this disease, especially the Native Americans of Mexico, Central America, and Southern America. As the lesions remain on the skin for long periods of time, sunshine tends to aggravate pre-existing rashes rather than produce new ones. In certain patients the rash will be the most severe in the months prior and following peak UV exposure due to the skin’s ability to become more tolerant as exposure to sunlight approaches its peak. Occasionally lesions will appear in the winter, although outbreaks tend to be most intense during months when the skin is most exposed to ultraviolet radiation. In 60-70% of patients a rash develops on the lips and conjunctiva of the eyes is found in 45%.Īctinic prurigo can last all year long with rashes sometimes taking weeks or months before they subside. A more mild reaction can sometimes be observed on those parts of the body that are hidden from the sun. These lesions are usually most intense on skin that has been exposed to UV radiation such as the face, neck, arms, and upper chest. The eruption produced tends to resemble eczema (atopic dermatitis) but is usually more severe. Actinic prurigo is a disorder that produces rashes consisting of tiny itchy red dots (papules).
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